Clinical effects of recombinant versus urinary gonadotropins in ovulation induction

Czech version

Authors: R. Středa ^1,2,3,4; D. Koryntová ²; Tonko Mardešič ^1,2; V. Sobotka ^1,2; J. Sobotková ^3,4
Authors‘ workplace: Sanatorium Pronatal, Praha, vedoucí lékař doc. MUDr. T. Mardešič, CSc. ¹; Sanatorium Pronatal Plus, Praha, vedoucí lékař MUDr. D. Koryntová, CSc. ²; Pardubická krajská nemocnice a. s., přednosta doc. MUDr. M. Košťál, CSc. ³; Fakulta zdravotnických studií, Univerzita Pardubice ⁴
Published in: Ceska Gynekol 2011; 76(2): 108-113

Overview

Objective:
To present an overview of trials and discussion focused on the clinical characteristics of recombinant gonadotropins compared with urinary ones in ovulation induction.

Subject:
Review article.

Setting:
Sanatorium Pronatal, Prague.

Subject and method:
The subject of the study is to compare the clinical characteristics of recombinant gonadotropins versus urinary ones focused on the daily dose of FSH achieving FSH threshold and the risk of multifollicular development in ovulation induction before intrauterine insemination, number of follicles and oocytes, the risk of ovarian hyperstimulation syndrome (OHSS), total consumption of FSH, cost effectiveness and expected pregnancy rate during in vitro fertilization technique.

The method is a MEDLINE research of articles from 1994 to 2010.

Conclusions:

Data demonstrates that recombinant FSH (rFSH) offers higher ovarian responce, less consumption of gonadotropins, lower risk of complications (multiple pregnancy and OHSS) compared with urinary FSH (uFSH). Expected pregnancy rate is probably comparable.

Key words:
ovulation induction, gonadotropins, recombinant FSH, urinary FSH, OHSS.

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