Quiscent trophoblastic disease
Authors:
F. Hron; V. Hejda; J. Feyereisl; P. Šafář; H. Sochová
Authors‘ workplace:
Ústav pro péči o matku a dítě, Praha, ředitel doc. MUDr. J. Feyereisl, CSc.
; Centrum pro trofoblastickou nemoc v ČR, Praha
Published in:
Ceska Gynekol 2011; 76(6): 443-446
Category:
Original Article
Overview
Type of study:
Case report.
Setting:
Center for trophoblastic disease in Czech Republic, Institute for care of mother and child, 3rd Faculty of Medicine of Charles University Prague.
Methods:
The autors present a case of quiscent trophoblastic disease diagnosed at 27 years old primipara, secundigravida after previous molar pregnancy. The patient had low levels of serum hCG present for more than 18 months after the termination of pregnancy. After this period there was a malignant transformation associated with rapid elevation of hCG levels with need for chemotherapy which was succesfully completed.
Conclusion:
Quiscent (dormant, noninvasive) trophoblastic disease is a recently described unit defined by low levels of hCG present in patients serum and urine samples without any evidence of trophoblastic tumour or other source of hCG production. Quiscent trophoblastic disease is associated with high risk of malignant transformation.
Key words:
quiscent, trophoblastic, noninvasive, persistent, hCG.
Sources
1. Cole, LA., Khanlian, SA. Inappropriate management of women with persistent low hCG results. J Reprod Med, 2004, 49, p. 423‑432.
2. Cole, LA., Shahabi, S., Oz, UA., et al. Hyperglycosylated hCG (invasive trophoblastic antigen) immunoassay: a new basis for gestational Down syndrome screening. Clin Chem, 1999, 45, p. 2109-2119.
3. Cole, LA., Kohorn, E., Harriet, O., Smith, MD. Gestational Trophoblastic Disease: Management of cases with persistent low human chorionic gonadotropin results. Obstet Gynecol Clin N Am, 2005, 32, p. 615-626.
4. Cole, LA., Miller, CY. Hyperglycosylated hCG in the management of quiscent and chemorefractory gestational trophoblastic disease. Gynecol Oncol, 2010, 116(1), p. 3-9.
5. Hancock, BW., Tidy, JA. Clinical management of persistent low level hCG elevation. Trophobl Dis Upd, 2004, 4, p. 5-6.
6. Khanlian, SA., Smith, HO., Cole, LA. Persistent low levels of hCG: a premalignant gestational trophoblastic disease. Am J Obstet Gynecol, 2003, 188, p. 1254-1259.
7. Kohorn, EI. Persistent low-level „real“ human chorionic gonadotropin: a clinical challenge and a therapeutic dilema. Gynecol Oncol, 2002, 85, p. 315-320.
8. Kovaleskaya, G., Genbacev, O., Fisher, SJ., et al. Trophoblast origin of hCG isoforms, cytotrophoblasts are the primary source of choriocarcinoma-like hCG. Mol Cell Endocrinol, 2002, 194, p. 147-155.
9. Zavadil, M. Trophoblastic disease. Praha: Acta Univ Carol Med, 1973, 19, 107 s.
10. Zavadil, M., Feyereisl, J., Krofta, L., et al. Persistent trophoblastic disease in Trophoblastic Disease Center in the Czech Republic in 1955-2007. Ces Gynek, 2008, 73(2), p. 73-79.
Labels
Paediatric gynaecology Gynaecology and obstetrics Reproduction medicineArticle was published in
Czech Gynaecology
2011 Issue 6
Most read in this issue
- Use of ultrasound in labor
- Compare of misoprostol and dinoprost effectivity by induced second-trimester abortion
- Prenatal diagnosis and management of fetuses with congenital diaphragmatic hernia
- Quiscent trophoblastic disease