Selective progesterone receptor modulators and their therapeutical use
Authors:
D. Driák 1
; B. Sehnal 1; I. Švandová 2
Authors‘ workplace:
Gynekologicko-porodnická klinika 1. LF UK a Nemocnice Na Bulovce, Praha, přednosta prof. MUDr. M. Halaška, DrSc.
1; Oddělení neurobiologie, Katedra fyziologie, Přírodovědecká fakulta UK, Praha
2
Published in:
Ceska Gynekol 2013; 78(2): 175-181
Overview
Currently developed selective progesterone receptor modulators (SPRMs) are steroid derived compounds with a bulky radical substitution at carbon 11. They interact with progesterone receptor and exert antagonistic or/and agonistic effects. Mifepristone was approved for pregnancy termination and ulipristal acetate as emergency contraception and pharmacological therapy of uterine fibroids. SPRMs inhibit endometrial proliferation and myoma growth, this suggests a therapeutical effect in cases of endometriosis and other estrogen-dependent diseases.
Keywords:
progesterone – progesterone receptor –selective progesterone receptor modulators – agonists and antagonists of progesterone – pregnancy termination – emergency contraception
Sources
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Labels
Paediatric gynaecology Gynaecology and obstetrics Reproduction medicineArticle was published in
Czech Gynaecology
2013 Issue 2
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