Solitary fibrous tumor of endometrium – a case report

Czech version

Authors: Ondřej Dvořák ¹ ; E. Dvořáková ¹; J. Laco ²; J. Špaček ¹
Authors‘ workplace: Porodnická a gynekologická klinika LF UK a FN, Hradec Králové, přednosta doc. MUDr. J. Špaček, Ph. D., IFEPAG ¹; Fingerlandův ústav patologie LF UK a FN, Hradec Králové, přednosta prof. MUDr. A. Ryška, Ph. D. ²
Published in: Ceska Gynekol 2013; 78(3): 302-305

Overview

Objective:
Solitary fibrous tumor (SFT) is an uncommon mesenchymal tumor. We present a case of SFT occurring in endometrium.

Design:
Case report.

Setting:
Department of Obstetrics and Gynecology, The Fingerland Department of Pathology, Medical Faculty of Charles University and Faculty Hospital Hradec Králové.

Case report:
We report a case of 57 years old woman with SFT arising from the endometrium, which was diagnosed and treated at our department. Histological finding was supported by typical immunohistochemical profile of the tumor. Aggressive nature of the tumor wasn’t showed. The patient underwent abdominal hysterectomy with bilateral adnexectomy and is followed up in regular periods.

Conclusion:
Occurence of solitary fibrous tumor (SFT) in the female genital tract is extremely rare. To the best of our knowledge, we report the first case of SFT occurring in endometrium. Because of potencial aggressive behaviour of the tumor complete surgical excision and close follow-up is highly recommended.

Keywords:
solitary fibrous tumor – uterus – endometrium – polyp

Sources

1. Alexandrakis, G., Johnson, TE. Recurrent orbital solitary fibrous tumor in a 14-year-old girl. Am J Ophthalmol, 2000, 130, p. 373–376.

2. Alston, SR., Francel, PC., Jane, JA. Jr. Solitary fibrous tumor of the spinal cord. Am J Surg Pathol, 1997, 21, p. 477–483.

3. Akiyama, Y., Nabeshima, K., Koita, H., et al. Solitary fibrous tumor of the vagina. Pathol Int, 2000, 50, p. 327–331.

4. Barnoud, R., Arvieux, C., Pasquier, D., et al. Solitary fibrous tumor of the liver with CD 34 expression. Histopathology, 1996, 28, p. 551–554.

5. Berzal-Cantalejo, F., Montesinos-Carbonell, M., Montesinos-Carbonell, ML., et al. Solitary fibrous tumor arising in the fallopian tube. Gynecol Oncol, 2005, 96, p. 880–882.

6. Chu, PW., Liu, JY., Peng, YJ., Yu, MH. Solitary fibrous tumor of the uterus. Taiwan J Obstet Gynecol, 2006, 45, p. 350–352.

7. Chilosi, M., Facchetti, F., Dei Tos, AP., et al. Bcl-2 expression in pleural and extrapleural solitary fibrous tumors. J Pathol, 1997, 181, p. 362–367.

8. England, DM., Hochholzer, L., McCarthy, MJ. Localized benign and malignant fibrous tumors of pleura. A clinical histopathological review of 223 cases. Am J Surg Pathol, 1989, 13, p. 640–658.

9. Falconieri, G., Lamovec, J., Mirra, M., Pizzolitto, S. Solitary fibrous tumor of the mammary gland: a potential pitfall in brest pathology. Ann Diagn Pathol, 2004, 8, p. 121–125.

10. Fletcher, CDM., Unni, KK., Mertens, F. Pathology and genetics of tumors of soft tissue and bone. World Health Organisation Classification of tumors. Lyon: IARC Press, 2002, p. 86–90.

11. Fukasawa, Y., Takada, A., Tateno, M., et al. Solitary fibrous tumor of pleura causing recurrent hypoglykemia by secretion of insuline like growth factor II. Pathol Int, 1998, 48, p. 47–52.

12. Fukonaga, M., Naganuma, H., Nikaido, T., et al. Extrapleural solitary fibrous tumor: A report of seven cases. Mod Pathol, 1997, 10, p. 443–450.

13. Fukunaga, M. Atypical solitary fibrous tumor of the vulva. Int J Gynecol Pathol, 2000, 19, p. 164–168.

14. Gelb, AB., Simmsons, ML., Weidner, N. Solitary fibrous tumor involving the renal capsule. Am J Surg Pathol, 1996, 20, p. 1288–1295.

15. Hanau, CA., Mittinen, M. Solitary fibrous tumor: Histo-pathological and immunohistochemical spectrum of benign and malignant variants presenting at different sites. Human Pathol, 1995, 26, p. 440–449.

16. Klemperer, P., Rabin, CB. Primary neoplasm of the pleura: A report of five cases. Arch Pathol, 1931, 11, p. 385–412.

17. Luttges, J., Mentzel, T., Hubner, G., et al. Solitary fibrous tumor of the pancreas: A new member of the small group of mesenchymal pancreatic tumours. Virchows Arch, 1999, 435, p. 37–42.

18. Nielson, GP., O’Connel, JX., Dickerson, GR., et. al. Solitary fibrous tumor of soft tissue : A report of 15 cases, including five malignant examples with light microscopic, immunohistochemical and ultrasound data. Mod Pathol, 1997, 10, p. 1028–1037.

19. Pinedo-Onofre, JA., Robles-Pérez, E., Peña-Mirabal, ES., Hernández-Carrillo, JA., et al. Giant solitary fibrous tumor of the pleura. Cir Ciruj, 2010, 78, p. 31–42.

20. Robinson, LA. Solitary fibrous tumor of the pleura. Cancer Control, 2006, 13, p. 264–269.

21. Vallat-Decouvelaere, AV., Dry, SM., Fletcher, CDM. Atypical and malignant solitary fibrous tumors in extrathoracic locations: evidence of their comparability to intrathoracic tumours. Am J Surg Pathol, 1998, 22, p. 1501–1511.

22. Wakami, K., Tateyama, H., Kawashima, H., et al. Solitary fibrous tumor of the uterus producing high-molecular-weight insulin-like growth factor II and associated with hypoglycemia. Int J Gynecol Pathol, 2004, 24, p. 79–84.

23. Zhao, G., Li, G., Han, R. Two malignant solitary fibrous tumors in one kidney: Case report and review of the literature. Oncol Lett, 2012, 4, p. 993–995.

24. Zubor, P., Kajo, K., Szunyogh, N., et al. A solitary fibrous tumor in the broad ligament of the uterus. Pathol Res Pract, 2007, 203, p. 555–560.