Benefits and the accuracy of the intra-operative frozen section at suspected ovarian tumours
Authors:
Milan Kudela
; R. Marek; R. Pilka; K. Huml; K. Horváthová
Authors‘ workplace:
Porodnicko-gynekologická klinika LF UP a FN, Olomouc, přednosta prof. MUDr. R. Pilka, Ph. D.
Published in:
Ceska Gynekol 2015; 80(4): 250-255
Overview
Objective:
To assess benefits and the accuracy of the intra-operative frozen section for the operative strategy at suspected ovarian tumours.
Type of study:
Retrospective study.
Setting:
Department of Obstetrics and Gynaecology, Faculty of Medicine and Dentistry, Palacky University in Olomouc.
Materials and methods:
Intraoperative frozen section and final histopathology were compared in 53 patients who underwent operative treatment for suspected ovarian neoplazma. The accuracy of the frozen section findings was evaluated according to the histopatological type of tumours and categories – benign, malignant and borderline tumours.
Conclusion:
In accordance with literature reports a good reliability of the frozen section as for the sensitivity, specificity, positive and negative predictive values were proved. The majority of errors occured in diagnosing mucinous and borderline tumours.
Keywords:
frozen section, ovarian tumour, accuracy of histopathological findings
Sources
1. Akrivos, N., Thomakos, N., Sotiropoulou, M., et al. Inoperative consultation in ovarian pathology. Gynecol Obstet Invest, 2010, 70, 3, p. 193–199.
2. Baker, P., Oliva, E. A practical approach to intraoperative consultation in gynecological pathology. Int J Gynecol Pathol, 2008, 27, 3, p. 353–365.
3. Bige, O., Demir, A., Savgili,U., et al. Frozen section diagnose of 578 ovarian tumors made by pathologists with and without expertise on gynecologic pathology. Gynecol Oncol, 2011, 123, 1, p. 43–46.
4. Brun, JL., Cortez, A., Rouzier, R, et al. Factors influencing the use and accuracy of frozen section diagnosis ef epithelial ovarian tumors. Am J Obstet Gynecol, 2008, 199, 3, p. 244–247.
5. Coumbos, A., Sehnuli, J., Cherekov, R., et al. Clinical mana-gement of borderline tumours of the ovary: results of a multicentre survey of 323 clinics in Germany. Br J Cancer, 2009, 100, 11, p. 1731–1738.
6. Gross, PA., Naik, R., Patel, A., et al. Intra-operative frozen section analysis for suspected early-stage ovarian cancer: 11 years of Gateshead Cancer Centre experience. BJOG, 2012, 119, p. 194–201.
7. Ganesan, R., Brown, LJ., Kehoe, S., et al. The role of frozen section in gynaecological oncology: survey of practice in the United Kingdom. Eur J Obstet Gynecol Reprod Biol, 2013, 166, 2, p. 204–208.
8. Ghaemmaghami, F., Fakour, F., Karimi Zachri, M., et al. Clinical assessment, gross examination, frozen section of ovarian masses: do patients benefit? Arch Gynecol Obstet, 2008, 278, 3, p. 209–213.
9. Gorisek, B., Rebolj Stare, M., Krajnc, I. Accuracy of Intra-Operative Frozen Section Analysis of Ovarian Tumours. Journal of International Med Res, 2009, 37, p. 1173–1177.
10. Gultekin, E., Gultekin, OE., Cingillioglu, B., et al. The value of frozen section evaluation in the management of borderline ovarian tumors. J Cancer Res Ther, 2011, 7, 4, p. 416–420.
11. Heatley, MK. A systematic review of papers examining the use of intraoperative frozen section in predicting the final diagnosis of ovarian lesions. Int J Gynaecol Pathol, 2012, 31, 2, p. 111–115.
12. Ilker, A., Aykut, B., Muge, H., et al. Accuracy of intra-operative frozen section in the diagnosis of ovarian tumours. J Pak Med Assoc, 2011, 61, 9, p. 856–858.
13. Kim, JH., Kim, JT., Park, YG., et al. Clinical analysis of intra-operative frozen section proven borderline tumors of the ovary. J Gynecol Oncol, 2009, 20,3, p. 176–180.
14. Kim, K., Chung, HH., Kim, JW., et al. Clinical impact of under-diagnosis by frozen section examination is minimal in borderline ovarian tumors. Eur J Surg Oncol, 35, 9, p. 969–973.
15. Lax, S., Tamussino, K., Prein, K., Lang, P. Intraoperative frozen section in diseases of the female genital tract. Pathologe, 2012, 33, 5, p. 430–440.
16. Maheshwri, A., Gusta, S., Kane, S., et al. Accuracy of intraoperative frozen section in the diagnosis of ovarian neoplazmas: Experience at a tertiary oncology center. World J Surgical Oncol, 2006, 4, 12.
17. Pongsuvareeyakul, T., Khunamornpong, S., Settakorn, J., et al. Accuracy of frozen–section diagnosis of ovarian mucinous tumors. Int J Gynecol Cancer, 2012, 22, 3, p. 400–406.
18. Rakhshan, A., Zham, H., Kazempour, M. Accuracy of frozen section diagnosis in ovarian masses: experience at a tertiary oncology center. Arch Gynecol Obstet, 2009, 280, 2, p. 223–228.
19. Shih, KK., Garg, K., Soslow, RA., et al. Accuracy of frozen section diagnosis of ovarian borderline tumor. Gynecol Oncol, 2011, 123, 3, p. 517–521.
20. Song,T., Choi, CH., Kin, HJ., et al. Accuracy of frozen section diagnosis of borderline ovarian tumors. Gynecol Oncol, 2011, 122, 1, p. 127–131.
21. Storms, AA., Sukumvanich, P., Monaco, SE., et al. Mucinous tumors of the ovary: diagnostic challenges at frozen section and clinical implications. Gynecol Oncol, 2012, 125, 1, p. 75–79.
22. Temfer, CB., Polterauer, S., Bentz, EK., et al. Accuracy of intraoperative frozen section analysis in borderline tumors of the ovary: a retrospective analysis of 96 cases and review of the literature. Gynecol Oncol, 2007, 107, 2, p. 248–252.
23. Toneva, F., Wright, H., Razvi, K. Accuracy of frozen section in the diagnosis of ovarian tumours. J Obstet Gynaecol, 2012, 32, 5, p. 479–482.
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Paediatric gynaecology Gynaecology and obstetrics Reproduction medicineArticle was published in
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