Comparison of vaginal use of micronized progesterone for the luteal support.
Randomized study comparison of Utrogestan and Crinone 8%
Authors:
L. Michnová 1; J. Dostál 2
; K. Langová 3
; T. Rumpíková 4; Milan Kudela 2
Authors‘ workplace:
IVF Clinic, Olomouc, vedoucí lékař MUDr. Š. Machač, Ph. D.
1; Porodnicko-gynekologická klinika FN a LF UP, Olomouc, přednosta prof. MUDr. R. Pilka, Ph. D.
2; Ústav lékařské biofyziky FN a LF UP, Olomouc, přednostka prof. RNDr. H. Kolářová, CSc.
3; Klinika reprodukční medicíny a gynekologie IVF, Zlín, odborný zástupce a ředitel kliniky MUDr. D. Rumpík
4
Published in:
Ceska Gynekol 2017; 82(1): 28-37
Overview
Objective:
The study was focused on comparison of efficiency, safety and tolerance of vaginal use of micronized progesterone in preparations Utrogestan and Crinone 8%.
Design:
Prospective randomized study.
Setting:
Department of Gynecology and Obstetric, University Hospital, Olomouc, Faculty of Medicine and Dentistry, Palacky University, Olomouc.
Material and methodology:
Into a prospective randomized study was, after calculation of 80% of the power of the study, α = 0,05, included 111 women in age between 18–40 with a basal value FSH < 10 IU/l and a normal finding in uteral cavity. After evaluation of efficiency of both preparations there was selected a fertilization rate, an implantation rate, a pregnancy rate and a take-home baby rate. Comparison of tolerance was made from evaluation of 21 parameters which were obtained through a questionnaire.
Results:
There were not been proven any significant differences in efficiency between both preparations. Crinone 8% was in patients better tolerated.
Conclusion:
Luteal support within the IVF/ICSI-ET remains an integral part of the treatment. According to the outcomes of the study it seems to be more suitable to use a vaginal gel for the luteal support with micronized progesterone.
Keywords:
luteal phase support, IVF/ET
Sources
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