The role of T-regulatory lymphocytes in pathogenesis of preterm delivery

Czech version

Authors: H. Hrbáčková ¹; M. Koucký ¹; K. Malíčková ²; A. Černý ¹; E. Gáborová ¹; H. Kopřivová ²; M. Hinďoš ²
Authors‘ workplace: Gynekologicko-porodnická klinika 1. LF UK a VFN, Praha, přednosta prof. MUDr. A. Martan, DrSc. ¹; Ústav lékařské biochemie a laboratorní diagnostiky 1. LF UK a VFN, Praha, přednosta prof. MUDr. T. Zima, DrSc., MBA ²
Published in: Ceska Gynekol 2017; 82(6): 487-490

Overview

Objective:
To describe the role of T-regulatory lymphocytes in pathogenesis of preterm delivery.

Setting:
Department of Obstetrics and Gynecology, General University Hospital and 1st Medical Faculty, Charles University, Prague.

Method:
T-regulatory lymphocytes modulate the immune system, secure the tolerance to own antigens and prevent autoimmune disease. During pregnancy is maternal immunity in contact with the semi-allogeneic fetus due to the fetomaternal crosstalk. It seems that maternal immunity and T-regulatory lymphocytes have an effect on premature birth and other pregnancy pathologies. According to the latest data, their role in the immunomodulation of pregnant women seems to be very significant, although we still do not understand many mechanisms.

Keywords:
T-regulatory cells, premature birth, immunomodulation in pregancy

Sources

1. Angela, XZ., Lina, K., Hodaka, F., Derya, U. GARP–TGF-β complexes negatively regulate regulatory t cell development and maintenance of peripheral CD4 + T cells in vivo. J Immunol, 2013, 190, p. 5057-5064; Prepublished online 10, April 2013; doi: 10.4049/jimmunol.1300065.

2. Asseman, C., Mauze, S., Leach, MW., et al. An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation. J Exp Med, 1999, 190, p. 995–1004.

3. Bulla, R., Bossi, F., Tedesco, F. The complement system at the embryo implantation site: friend or foe? Frontiers in immunology, 2012, 3, p. 55.

4. Cao, X., Cai, SF., Fehniger, TA., et al. Granzyme B and perforin are important for regulatory T cell-mediated suppression of tumor clearance. Immunity, 2007, 27, p. 635–646.

5. Deaglio, S., Dwyer, KM., Gao, W., et al. Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression. J Exp Med, 2007, 204, p. 1257–1265.

6. Fallarino, F., Grohmann, U., Hwang, KW., et al. Modulation of tryptophan catabolism by regulatory T cells. Nat Immunol, 2003, 4, p. 1206–1212.

7. Heikkinen, J., Mottonen, M., Alanen, A., Lassila, O. Phenotypic characterization of regulatory T cells in the human decidua. Clin Exp Immunol, 2004, 136, p. 373–378.

8. Koucký, M., Malíčková, K., Cindrová-Davies, T., et al. Low levels of circulating T-regulatory lymphocytes and short cervical length are associated with preterm labor. J Reprod Immunol, 2014, 106, p. 110–117.

9. Koucký, M., Vráblíková, H. Nové možnosti predikce předčasného porodu. Actual Gyn, 2014, 6, s. 40-44.

10. Leber, A., Teles, A., Zenclussen, AC. Regulatory T cells and their role in pregnancy. Am J Reprod Immunol, 2010, 63(6), p. 445–459.

11. Lee, SE., Romero, R., Jung, H., et al. The intensity of the fetal inflammatory response in intraamniotic inflammation with and without microbial invasion of the amniotic cavity. Am J Obstet Gynecol, 2007, p. 291–296.

12. Loser, K., Apelt, J., Voskort M., et al. IL-10 controls ultraviolet-induced carcinogenesis in mice. J Immunol, 2007, 179, p. 365–371.

13. Malíčková, K., Koucký, M., Vráblíková H. T-lymfocyty ve fyziologické a patologické graviditě. Alergie, 2014, 16/2, s. 115–121 (elektronická verze).

14. Pandiyan, P., Zheng, L., Ishihara, S., et al. CD4+ CD25+ Foxp3+ regulatory T cells induce cytokine deprivation-mediated apoptosis of effector CD4+ T cells. Nat Immunol, 2007, 8, p. 1353–1362.

15. Prins, JR., Boelens, HM., Heimweg, J., et al. Preeclampsia is associated with lower percentages of regulatory T cells in maternal blood. Hypertens Pregnancy, 2009, 28/3, p. 300–311.

16. Ren, X., Ye, F., Jiang, Z., et al. Involvement of cellular death in TRAIL/DR5-dependent suppression induced by CD4(+)CD25(+) regulatory T cells. Cell Death Differ, 2007, 14, p. 2076–2084.

17. Rowe, JH., Ertelt, JM., Xin, L., Way, SS. Pregnancy imprints regulatory memory that sustains anergy to fetal antigen. Nature, 2012, 490(7418), p. 102–106

18. Saito, S., Nakashima, A., Shima, T., Ito, M. Th1/Th2/Th17 and regulatory T-cell paradigm in pregnancy. Am J Reprod Immunol, 2010, 63(6), p. 601–610.

19. Sanchez-Ramon, S., Navarro, AJ., Aristimuno, C., et al. Pregnancy-induced expansion of regulatory T-lymphocytes may mediate protection to multiple sclerosis activity. Immunol Lett, 2005, 96, p. 195–201.

20. Sasaki, Y., Sakai, M., Miyazaki, S., et al. Decidual and peripheral blood CD4+CD25+ regulatory T cells in early pregnancy subjects and spontaneous abortion cases. Mol Hum Reprod, 2004, 10, p. 347–353.

21. Schumacher, A., Wafula, PO., Bertoja, AZ., et al. Mechanisms of action of regulatory T cells specific for paternal antigens during pregnancy. Obstet Gynecol, 2007, 110, p. 1137–1145.

22. Singh, J., Ahmed, A., Girardi, G. Role of complement component C1q in the onset of preeclampsia in mice. Hypertension, 2011, 58, p. 716–724.

23. Somerset, DA., Zheng, Y., Kilby, MD., et al. Normal human pregnancy is associated with an elevation in the immune suppressive CD25+ CD4+ regulatory T-cell subset. Immunology, 2004, 112, p. 38–43.

24. Steinborn, A., Schmitt, E., Kisielewicz, A., et al. Pregnancy-associated diseases are characterized by the composition of the systemic regulatory T cell (Treg) pool with distinct subsets of Tregs. Clin Exp Immunol, 2012, 167(1), p. 84–98.

25. Stockis, J., Colau, D., Coulie, PG., Lucas, S. Membrane protein GARP is a receptor for latent TGF-b on the surface of activated human Treg. Eur J Immunol, 2009, 39, p. 3315–3322

26. Wang, R., Kozhaya, L., Mercer, F., et al. Expression of GARP selectively identifies activated human FOXP3+ regulatory T cells. Proc Natl Acad Sci USA, 2009, 106(32), p. 13439–13444.

27. Winger, EE., Reed, JL. Low circulating CD4(+) CD25(+) Foxp3(+) T-regulatory cell levels predict miscarriage risk in newly pregnant women with a history of failure. Am J Reprod Immunol, 2011, 66(4), p. 320–328.

28. Xiong, H., Zhou, C., Qi, G. Proportional changes of CD4+ CD25+ Foxp3+ regulatory T cells in maternal peripheral blood during pregnancy and labor at term and preterm. Clin Invest Med, 2010, 33(6), p. 422.

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Article was published in

Czech Gynaecology

2017 Issue 6