Elevated serum concentrations of S100–A11 and AIF-1 in cervical dysplasia patients
Authors:
Maděrka M. 1; Dvořák V. 2; Hambálek J. 1; Stejskal D. 3,4; Krejčí G. 3; Švesták M. 3; Langová K. 5; Pilka R. 1
Authors‘ workplace:
Porodnicko-gynekologická klinika LF UP a FN Olomouc
1; Centrum ambulantní gynekologie a primární péče, Brno
2; Oddělení laboratorní medicíny, AGEL Středomoravská nemocniční, a. s., Prostějov
3; Ústav laboratorní diagnostiky, FN Ostrava 5 Ústav lékařské biofyziky, LF UP v Olomouci
4
Published in:
Ceska Gynekol 2021; 86(1): 11-15
Category:
Original Article
doi:
https://doi.org/10.48095/cccg202111
Overview
Objective: The aim of this study was to compare TFF3, AIF-1, S100–A11 and DKK1 serum levels in patients with cervical dysplasia, and in healthy female controls.
Methods: The first group included 59 patients with a histological diagnosis of precancerous disease CIN 1. The second group included 198 patients with a histological diagnosis of precancerous disease CIN 2 or CIN 3. The control group was comprised of 90 patients who underwent elective total hysterectomy for nonmalignant disorders. In all patients, preoperative serum samples were taken and separated; the sera were all stored at -80°C until the analysis for TFF3, AIF-1, S100–A11 and DKK1.
Results: The serum levels of S100–A11 (P < 0.0001) and AIF-1 (P < 0.0001) were statistically significantly higher in patients with mild precancerous lesions (CIN 1) than in controls. The levels of TFF3 and DKK1 were not statistically significantly different in patients with CIN 1 and in the control group. The serum levels of S100–A11 (P < 0.0001) and AIF-1 (P < 0.0001) were statistically significantly higher in patients with severe precancerous lesions (CIN 2/3) than in controls. TFF3 and DKK1 levels were not statistically significantly different in patients with CIN 2/3 compared to controls.
Conclusion: S100–A11 and AIF-1 represent potential biomarkers in patients with cervical dysplasia.
Keywords:
oncogynecology – cervical dysplasia – biomarkers – precancerous cerviw – S100–A11 – TFF-3 – AIF-1 – DKK1
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Paediatric gynaecology Gynaecology and obstetrics Reproduction medicineArticle was published in
Czech Gynaecology
2021 Issue 1
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