Intrahepatic cholestasis of pregnancy

Czech version

Authors: Luděk Kostka ; Lukáš Hruban ; Petra Morávková
Authors‘ workplace: Gynekologicko-porodnická klinika LF MU a FN Brno
Published in: Ceska Gynekol 2024; 89(5): 405-410
Category:
doi: https://doi.org/10.48095/cccg2024405

Overview

Objective: The aim of this work is to summarize current scientific information focusing on the diagnosis, management, and treatment of intrahepatic cholestasis in pregnancy according to available literature. Methodology: Literature sources were searched using the Web of Science, Scopus, and PubMed/Medline databases. Conclusion: For the diagnosis and proper management of intrahepatic cholestasis of pregnancy, the postprandial serum bile acid value of the pregnant woman is crucial. Postprandial testing allows for a higher likelihood of identifying patients with significantly elevated bile acid levels. Bile acid values above 100 µmol/l, especially in the 3^rd trimester, are associated with a significant risk of severe complications, particularly intrauterine fetal death. Ursodeoxycholic acid, the first-line treatment, according to available data, does not improve perinatal outcomes and has minimal effect on the sensation of itching in patients. The routine administration of ursodeoxycholic acid in the treatment of intrahepatic cholestasis of pregnancy is controversial.

Keywords:

ursodeoxycholic acid – bile acids – intrahepatic cholestasis of pregnancy

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ORCID autorů

L. Kostka 0009-0001-6553-4471

L. Hruban 0000-0001-8594-2678

P. Morávková 0000-0001-6613-9476

Doručeno/Submitted: 18. 6. 2024

Přijato/Accepted: 22. 7. 2024

doc. MUDr. Lukáš Hruban, Ph.D.

Gynekologicko-porodnická klinika

LF MU a FN Brno

Obilní trh 11

625 00 Brno

hruban.lukas@fnbrno.cz