Importance of basal fibroblast growth factor levels in patients with ovarian tumor
Authors:
V. Študent 1; C. Andrýs 2
; O. Souček 2
; J. Špaček 1; J. Tošner 1; I. Sedláková 1
Authors‘ workplace:
Porodnická a gynekologická klinika LF UK a FN, Hradec Králové, přednosta doc. MUDr. J. Špaček, Ph. D.
1; Ústav klinické imunologie a alergologie FN, Hradec Králové, přednosta prof. RNDr. J. Krejsek, CSc.
2
Published in:
Ceska Gynekol 2018; 83(3): 169-176
Overview
Objective:
Evaluation of importance of serum levels of basic fibroblast growth factor (bFGF) in patients with ovarian cancer, patients with border-line ovarian tumor, patients with benign ovarian cyst and women with normal ovarian tissue.
Design:
Prospective clinical study.
Setting:
Department of Gynecology and Obstetrics, Charles University, Faculty of Medicine in Hradec Kralove and University Hospital Hradec Kralove.
Methods:
Measurement of serum levels of bFGF by ELISA using reagents of company R&D Systems prior to treatment in a total of 74 consecutive coming women.
Results:
Serum level of bFGF from peripheral blood before treatment was significantly higher (p < 0.05) in patients with newly diagnosed ovarian cancer (n = 22), Med = 10.35 pg/ml (1.2–46.2 pg/ml) compared to patients with a border-line ovarian tumor (n = 9), Med = 5.4 pg/ml (1.6–6.8 pg/ml), patients with benign ovarian cyst (n = 24), Med = 5.2 pg/ml (0.1–67.2 pg/ml), and to women with normal ovarian tissue (n = 19) Med = 4.3 pg/ml (0.9–13.4 pg/ml). There isn‘t strong linear correlation (Spearman‘s rank correlation coefficient = 0.208791) between the serum level of bFGF and CA125 collected from peripheral blood before primary surgery or neoadjuvant chemotherapy in a group of patients with ovarian cancer (n = 14). We have not found significance correlation between age and serum levels of bFGF in patients with ovarian cancer, with border-line ovarian tumor, with benign ovarian cyst and in women with normal ovarian tissue.
Conclusion:
Serum levels of bFGF in patients with ovarian cancer are significantly higher than in patients with a border-line ovarian tumor, with benign ovarian cyst and in women with normal ovarian tissue regardless of age of patients.
Keywords:
ovarian cancer, basic fibroblast growth factor (bFGF), angiogenesis
Sources
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Paediatric gynaecology Gynaecology and obstetrics Reproduction medicineArticle was published in
Czech Gynaecology
2018 Issue 3
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