Epidemiology and significance of surgical margins in the management of HPV-associated vulvar precancers (H-SIL) – analysis of own data
Authors:
T. Pichlík 1,2
; Lukáš Rob 1
; Michael Jiří Halaška 1
; J. Drozenová 3
; H. Robová 1
Authors‘ workplace:
Gynekologicko-porodnická klinika 3. LF UK a FNKV, Praha
1; Lékařská fakulta, UK v Plzni
2; Ústav patologie 3. LF UK a FNKV, Praha
3
Published in:
Ceska Gynekol 2022; 87(6): 384-387
Category:
Original Article
doi:
https://doi.org/10.48095/cccg2022384
Overview
Objective: Epidemiology and evaluation of the importance of surgical margins in the treatment of vulvar H-SIL – analysis of own data. Material and methods: The prospective study included women diagnosed with HPV-associated vulvar epithelial neoplasia from 10/2016 to 1/2022. A total of 65 women were included. After surgical treatment, the women were distributed to groups according to surgical margins and were followed-up at regular intervals. Results: Seventeen women (26%) diagnosed with HPV-associated vulvar intraepithelial neoplasia were under 49 years, whereas 48 women (74%) were older than 49 years. Recurrence rates of HPV-associated precancers were 12.3%, 1.5% and 3.1% in excisions with positive margins up to 1 mm peripheral margins and 1–3 mm peripheral margins, respectively. The risk of recurrence when the lesion reaches the margin is statistically significant, compared to a healthy margin of 1–3 mm. Conclusion: Keeping the minimal healthy margin (1–3 mm) seems to be an acceptable risk of recurrence of HPV-associated vulvar intraepithelial neoplasia with positive cosmetic effect and minimal risk of disturbing the psychosexual functions of women. Long-term regular follow-up is necessary.
Keywords:
Epidemiology – vulvar intraepithelial neoplasia – H-SIL – surgical margins
Sources
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Paediatric gynaecology Gynaecology and obstetrics Reproduction medicineArticle was published in
Czech Gynaecology
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