Use of antipsychotics during pregnancy and their impact on congenital malformations and early neonatal adaptation
Authors:
K. Hrdličková 1,2
; H. Němcová 1,2
; A. Horáková 1,2
; A. Šebela 1,3
Authors‘ workplace:
Národní ústav duševního zdraví, Klecany
1; Katedra psychologie, FF UK, Praha
2; 3. LF UK, Praha
3
Published in:
Ceska Gynekol 2023; 88(3): 221-230
Category:
doi:
https://doi.org/10.48095/cccg2023221
Overview
Objective: Review of recent literature dealing with the effect of antipsychotic use during pregnancy on early postpartum adaptation of exposed infants and the development of congenital malformations. Results: The use of antipsychotics during pregnancy does not appear to lead to significantly higher risk of congenital malformations but may pose a greater risk for the early adaptation of the newborn (especially the risk of preterm birth and intensive care unit admission). The study to date face methodological limitations – lack of information on exact doses of antipsychotics, lack of control groups of women with psychiatric problems but not taking antipsychotics and failure to control for confounding factors. Conclusion: The available data suggest the relative safety of antipsychotics during pregnancy, provided that potential risks are known, and the woman and her baby are carefully monitored.
Keywords:
childbirth – Antipsychotics – newborn – pregnancy – congenital malformation
Sources
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Labels
Paediatric gynaecology Gynaecology and obstetrics Reproduction medicineArticle was published in
Czech Gynaecology
2023 Issue 3
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